Team Leader : Vincent Cavaillès
Institut de Recherche en
Cancérologie de Montpellier
CRLC Val d’Aurelle-Paul Lamarque
34298 Montpellier cedex 5 |
|
Tél. 33 (0)4 67 61 24 05
Tél/Sec. 33 (0)4 67 61 85 77
Fax. 33 (0)4 67 61 37 87
v.cavailles@valdorel.fnclcc.fr |
Research topics
The main objective of our team is to decipher the molecular mechanisms of hormone signaling by nuclear receptors (NRs). These NRs are involved in the proliferation of hormone-dependant cancer (breast and prostate) which constitute major challenges of public health. Following our recent data, our projects are focused on two types of regulators of NR activity : environmental ligands and transcription cofactors.
The first goal is to identify endocrine disruptors which interfere with hormone signaling. Such molecules present in various environmental or biological samples (river water and sediments, adipose tissues from patients with breast cancer) will be characterized using bioluminescent cell lines established in our laboratory. The various active molecules will be identified and further characterized in vivo on the bioluminescent cells grafted on nude mice.
more informations ...
|
|
Main Publications
Badia E, Escande A, Balaguer P, Metivier R, Cavailles V. New stably transfected bioluminescent cells expressing FLAG epitope-tagged estrogen receptors to study their chromatin recruitment. BMC Biotechnol 2009; 9: 77
more informations ... |
