Our project is based on recent data obtained by the team that open new perspectives on the participation and/or the mode of action of specific relevant genes implicated in tumor progression. The precise genes studied include two transcription factors (estrogen receptor and Fra-1, a FOS family member) and one enzymes (the protein tyrosine phosphatase PTPL1). These genes were selected on account of their key roles in cell proliferation and invasion evidenced by in vitro cell culture studies and in vivo xenograft models and some of them have already been associated with a favourable (ER PTPL1) prognostic value in breast cancer.
Although estrogens are mitogenic in human breast cancer cells, numerous studies have shown that estrogen receptor (ER)- positive breast cancers have a better prognosis than breast carcinomas which lack ER expression. ER- breast cancers exhibit often a higher ability to metastasize and introduction of ER in ER- cells inhibits cell proliferation and invasion in the absence of estrogens. One of our objective is therefore to precise how ER could have a protective role in breast cancer aggressiveness.
Glondu-Lassis M, Dromard M, Lacroix-Triki M, Nirdé P, Puech C, Knani D, Chalbos D, Freiss G. PTPL1/PTPN13 Regulates Breast Cancer Cell Aggressiveness through Direct Inactivation of Src Kinase. Cancer Res. 2010 May 25. [Epub ahead of print]PMID: 20501847
Nirdé P, Derocq D, Maynadier M, Chambon M, Gary-Bobo M, Garcia M (2010) Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells, Oncogene, 29:117-27.
Wang X, Belguise K, O’Neill C, Eddy SF, Mineva ND, Yu Z, Sánchez-Morgan N, Min C, Trinkaus-Randall V, Chalbos D, Sonenshein GE (2009) RelB NF-B Represses Oestrogen Receptor Expression via Induction of the Zinc Finger Protein Blimp1. Mol Cell Biol, 29:3832-3844.
Revillion F, Puech C, Rabenoelina F, Chalbos D, Peyrat JP, Freiss G. Expression of the putative tumor suppressor gene PTPN13/PTPL1 is an independent prognostic marker for overall survival in breast cancer. Int J Cancer 2008; 124: 638-643.
