Team Leader : Pierre Martineau
Institut de Recherche en
Cancérologie de Montpellier
CRLC Val d’Aurelle-Paul Lamarque
34298 Montpellier cedex 5
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Tél. 33 (0)4 67 61 37 43
Fax 33 (0)4 67 61 37 87
pierre.martineau@inserm.fr |
Research topics
The team has mainly developed three topics in the last years :
- Analysis of tumor samples from patients with metastatic colorectal cancers, treated with an Irinotecan/5-FU chemotherapy, using DNA arrays to determine genes important in tumor response to therapy.
- Establishment of adenocarcinoma cell lines with in vitro acquired resistance to drugs (SN38, oxaliplatine, 5-FU).
- A new and original approach, using intracellular antibodies, to screen for molecules able to modulated with a high specificity signaling pathways.
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Main Publications
Thierry AR, Mouliere F, Gongora C, Ollier J, Robert B, Ychou M, Del Rio M, Molina F. Origin and quantification of circulating DNA in mice with human colorectal cancer xenografts. Nucleic Acids Res. 2010 May 21. [Epub ahead of print]PMID: 20494973
Bonfils C, Bec N, Larroque C, Rio MD, Gongora C, Pugnière M, Martineau P. Cyclophilin A as negative regulator of apoptosis by sequestering cytochrome c. Biochem Biophys Res Commun. 2010 Mar 5;393(2):325-30.
Amina Bouslimani, Nicole Bec, Matthias Glueckmann, Christophe Hirtz and Christian Larroque. Matrix-assisted laser desorption/ionization imaging mass spectrometry of oxaliplatin derivatives in heated intraoperative chemotherapy (HIPEC)-like treated rat kidney. Rapid Commun. Mass Spectrom. 2010; 24: 415421
Estephan E, Saab MB, Larroque C, Martin M, Olsson F, Lourdudoss S, Gergely C. Peptides for functionalization of InP semiconductors. J Colloid Interface Sci. 2009 Sep 15;337(2):358-63. Epub 2009 May 25. PubMed PMID: 19539948.
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