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Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avancès C, Allory Y, de la Taille A, Culine S, Blancou H, Cristol JP, Michel F, Sardet C, Fajas L. Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice. Mol Cancer Ther. 2010 Jun 8. [Epub ahead of print]
Fritz V, Fajas L. Metabolism and proliferation share common regulatory pathways in cancer cells. Oncogene. 2010 May 31. [Epub ahead of print]
Fajas L, Blanchet E, Annicotte JS. CDK4, pRB and E2F1: connected to insulin. Cell Div. 2010 Feb 5;5(1):6.PMID: 20181095
Blanchet E, Annicotte JS, Fajas L. Cell cycle regulators in the control of metabolism. Cell Cycle. 2009 Dec 15;8(24):4029-31.
Annicotte JS, Blanchet E, Chavey C, Iankova I, Costes S, Assou S, Teyssier J, Dalle S, Sardet C, Fajas L. The CDK4-pRB-E2F1 pathway controls insulin secretion. Nat Cell Biol. 2009 Aug;11(8):1017-23.
Clapé C, Fritz V, Henriquet C, Apparailly F, Fernandez PL, Iborra F, Avancès C, Villalba M, Culine S, Fajas L. miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice. PLoS One. 2009 Oct 26;4(10):e7542.
Chavey C, Lazennec G, Lagarrigue S, Clape C, Iankova I, Teyssier J, Annicotte JS, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, Renard E, Strieter R, Tuthill A, Hotamisligil GS, Vidal-Puig A, Zorzano A, Langin D, Fajas L. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab 2009; 9: 339-349.
Iankova I, Chavey C, Clape C, Colomer C, Guerineau NC, Grillet N, Brunet JF, Annicotte JS, Fajas L. RGS4 controls fatty acid and glucose homeostasis. Endocrinology 2008; 149: 5706-5712
Abella, A., Dubus, P., Malumbres, M., Rane, S. G., Kiyokawa, H., Sicard, A., Vignon, F., Langin, D., Barbacid, M., and Fajas, L. Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metab, 2: 239-249, 2005.
Dali-Youcef, N., Mataki, C., Coste, A., Messaddeq, N., Giroud, S., Blanc, S., Koehl, C., Champy, M. F., Chambon, P., Fajas, L., Metzger, D., Schoonjans, K., and Auwerx, J. Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure. Proc Natl Acad Sci U S A, 2007.
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Annicotte, J. S., Iankova, I., Miard, S., Fritz, V., Sarruf, D., Abella, A., Berthe, M. L., Noel, D., Pillon, A., Iborra, F., Dubus, P., Maudelonde, T., Culine, S., and Fajas, L. Peroxisome proliferator-activated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer. Mol Cell Biol, 26: 7561-7574, 2006.
Iankova, I., Petersen, R. K., Annicotte, J. S., Chavey, C., Hansen, J. B., Kratchmarova, I., Sarruf, D., Benkirane, M., Kristiansen, K., and Fajas, L. Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis. Mol Endocrinol, 20: 1494-1505, 2006.
Sarruf, D. A., Iankova, I., Abella, A., Assou, S., Miard, S., and Fajas, L. Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma. Mol Cell Biol, 25: 9985-9995, 2005.
Annicotte, J. S., Chavey, C., Servant, N., Teyssier, J., Bardin, A., Licznar, A., Badia, E., Pujol, P., Vignon, F., Maudelonde, T., Lazennec, G., Cavailles, V., and Fajas, L. The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene. Oncogene, 24: 8167-8175, 2005.
Fajas, L., Annicotte, J. S., Miard, S., Sarruf, D., Watanabe, M., and Auwerx, J. Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/-)mice. J Clin Invest, 113: 1288-1295, 2004.
Fajas, L., Egler, V., Reiter, R., Hansen, J., Kristiansen, K., Debril, M. B., Miard, S., and Auwerx, J. The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev Cell, 3: 903-910, 2002.
Fajas, L., Landsberg, R. L., Huss-Garcia, Y., Sardet, C., Lees, J. A., and Auwerx, J. E2Fs regulate adipocyte differentiation. Dev Cell, 3: 39-49, 2002.
Fajas, L., Paul, C., Zugasti, O., Le Cam, L., Polanowska, J., Fabbrizio, E., Medema, R., Vignais, M. L., and Sardet, C. pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F. Proc Natl Acad Sci U S A, 97: 7738-7743, 2000.
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