Research
Epithelial Growth and Cancer : A. Djiane

In healthy tissues, cell behaviours such as proliferation and adhesion are tightly controlled, ensuring the harmonious growth of tissues and organs. This control is achieved through cellular interactions and short- and long-distance exchanges of information that must then be integrated. Invariably, cancer cells adapt and escape these strict regulations to proliferate and invade surrounding or distant tissues. Using complementary approaches and experimental models, the 'Epithelial growth and cancer' team is seeking to understand how short- and long-distance signalling is integrated in epithelial cells and how their alterations contribute to tumour development. More specifically, we are studying

1. the role of the Hippo tumour suppressor signalling pathway, and how it is regulated

2. cell competition and its influence on tissue and tumour composition

3. interactions between the tumour and the body, particularly during cachexia.

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