Our research is organized around 3 closely related research themes
Research Summary
Our research focuses on the treatment of solid tumors by using antibodies and radiotherapy with a special attention to drug-induced resistance. To this aim, we design, develop and evaluate monoclonal antibodies (mAbs) to target antigens the expression of which is enhanced when tumors become resistant to a treatment and we combine them to identify synthetic lethal interactions for anti-cancer drug discovery/improvement.
Our main objectives are: (i) to design and develop new antibodies and derived molecules; (ii) to improve the efficacy of these targeted therapeutic approaches; and (iii) to understand the underlying mechanisms of action.
Responsable : André Pèlegrin Institut de Recherche en Tél. : 33 (0)4 67 61 30 32
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