Kyoto Univ, Japan
In human cancer, malignant cells reprogram and rewire cellular metabolic networks for robust growth and maintenance and adaptation to their microenvironment. Such altered metabolism often leads to dependency on specific nutrients, and therefore, targeting cancer-specific metabolism would be an effective therapeutic strategy. To achieve the long-term goal, it is essential to identify metabolic vulnerabilities in human malignancy, and I would like to share our recent findings on the roles of the branched-chain amino acid (BCAA) metabolism in myeloid leukemia.
Contact : Andrei Turtoi at Inserm