Postdoctoral Position in Modeling of the Tumor MicroenvironmentDate limite de candidature : 31/12/2019The Colinge Laboratory Cancer Bioinformatics and Systems Biology at IRCM (Cancer Research Institute of Montpellier) is looking for a talented postdoctoral fellow to work on the evolution of the tumor microenvironment (TME) in response to therapy. This computational work will build upon on-going developments conducted in the lab to infer cellular interactions taking place in the TME. Both single-cell and bulk transcriptomics configurations will be considered. A significant part of the research will relate to lung adenocarcinoma and involve a consortium of expert laboratories in lung cancer and mouse models thereof, animal computer tomography, and 3D imaging. The postdoc position is funded for three years; a 1-year contract will be offered first and extended for another two years based on performance. Preferred qualifications are a bioinformatics Ph.D. with solid computational skills or a mathematics, physics, or computer science Ph.D. with strong interests in life science applications. Interested applicants should e-mail their CV, a letter of motivation, and the names and e-mails of 2 references to Prof Jacques Colinge (at inserm.fr). Applications will be studied immediately. Selected publicationsAlame et al., The molecular landscape and microenvironment of salivary duct carcinoma reveal new therapeutic opportunities, bioRxiv, 2019Lehmann et al., In Vivo Large-Scale Mapping Of Protein Turnover In The Human Cerebrospinal Fluid, bioRxiv, 2019Blomen et al. Gene essentiality and synthetic lethality in haploid human cells. Science, 2015Pichlmair et al. Viral immune modulators perturb the human molecular network by common and unique strategies, Nature, 2012Stukalov et al. Deconvolution of targeted protein-protein interaction maps. J Proteome Res, 2012  

Mathias ChamaillardCentre d'Infectieux et d'Immunité de Lille UMR 1019 INSERM, Institut Pasteur, Lille"Cultiver la flore intestinale pour vaincre le cancer"Contact Université Tours : Nathalie Vourch

Adrien Laroche of Dr André Pélegrin's team will defend his PhD thesis on "A novel type of bispecific antibody with targeted depletion activity of soluble pro-tumoral factors in the tumor microenvironment for cancer therapy" This Wednesday 3 December at 14:00, IRCM seminar room

Diane Nishimwe of Dr Emma Liaudet Coopman's team will defend his PhD thesis on "New targeted therapy of breast cancer : Targeting tumor microenvironment With human anti-cathepsin D Antibody Drug Conjugates" This Wednesday 11 December at 10:00, Epidaure seminar room

L’Institut de Recherche en Cancérologie de Montpellier a inauguré, le 18 septembre 2019, une plateforme d’imagerie par cytométrie de masse basée sur la technologie CyTOF/Hyperion permettant, pour la première fois en France, de cartographier le microenvironnement cellulaire et l’hétérogénéité tumorale. Cette technologie, unique en France, est porteuse de nouveaux espoirs pour les patients. Elle devrait permettre, à l’heure où l’immunothérapie a des effets cliniques spectaculaires, y compris chez des patients en échappement thérapeutique, d’approfondir la connaissance sur ces nouvelles thérapies anticancéreuses.    Communiqué de presse Inauguration CyTOF IRCM