Nuclear signaling and cancer : V. Cavaillès


The main scientific objective of the "Nuclear Signaling and Cancer" team is to decipher the transcriptional networks controlling the expression of key genes involved in the control of cell homeostasis and to understand how their deregulation contributes to cancer formation and progression. Our work focuses on the transcriptional coregulators RIP140 and LCoR and on their action in different oncogenic signaling pathways including nuclear receptors. We are also studying the peptidyl deiminase PADIs, their role in arginine citrullination, in the control of genome organization and tumorigenesis, and the potential implication in therapeutic strategies. In parallel, we are developing a more applied research in collaboration with chemists, aimed at developing new biomaterials for the treatment of bone metastases of breast cancer. The expected results are 1) a better understanding of the molecular mechanisms of tumorigenesis and of the resistance of cancers to treatment, 2) the identification of new diagnostic and/or prognostic markers and new medical devices or therapeutic approaches to improve the management of gastrointestinal and gynecological cancers. 



Belaid H, Nagarajan S, Teyssier C, Barou C, Garay H, Huon V, Cornu D, Cavaillès V, Bechelany M Development of new biocompatible 3D printed graphene oxide-based scaffolds. Mater Sci Eng C Mater Biol Appl. 2020;110. doi:10.1016/j.msec.2019.110595

Linares A, Assou S, Lapierre M, Thouennon E, Duraffourd C, Fromaget C, Boulahtouf A, Tian G, Ji J, Sahin O, Badia E, Boulle N, Cavaillès V Increased expression of the HDAC9 gene is associated with antiestrogen resistance of breast cancers. Mol Oncol. 2019;13(7):1534-1547. doi:10.1002/1878-0261.12505

Sixou S, Müller K, Jalaguier S, Kuhn C, Harbeck N, Mayr D, Engel J, Jeschke U, Ditsch N, Cavaillès V Importance of RIP140 and LCoR Sub-Cellular Localization for Their Association With Breast Cancer Aggressiveness and Patient Survival. Transl Oncol. 2018;11(5):1090-1096. doi:10.1016/j.tranon.2018.06.006

Jalaguier S, Teyssier C, Nait Achour T, Lucas A, Bonnet S, Rodriguez C, Elarouci N, Lapierre M, Cavailles V Complex regulation of LCoR signaling in breast cancer cells. Oncogene. 2017;36(33):4790-4801.

Lapierre M, Bonnet S, Bascoul-Mollevi C, Ait-Arsa I, Jalaguier S, Del Rio M, Plateroti M, Roepman P, Ychou M, Pannequin J, Hollande F, Parker M, Cavailles V RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. The Journal of clinical investigation. 2014;124. doi:10.1172/JCI65178


Institut de Recherche en
Cancérologie de Montpellier
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