Chady JaberSyntego Inc“ How to Use the Power of CRISPR in Functional Genomics and Biomarkers Discovery”This seminar dedicated to researchers at the IRCM will cover the following topics:    • CRISPR Experimental Design and Optimization (Knock-outs and Knock-ins)     • Synthego robust loss of function screens for confident target discovery    • Using CRISPR to uncover protein functions and pathway analysis Join us for an interactive session about the latest CRISPR advances and applications. Discover the impact of CRISPR in cancer and genetic disease research. Inscription obligatoire : https://www.synthego.com/events/ircm-virtual-crispr-seminar-05-20-2021?utm_campaign=Seminar&utm_medium=email&_hsmi=2&_hsenc=p2ANqtz-_sudq5Q7awlTD2lNg-tEEocSrQCLkfy39t8xve_RgWiIslJQj6y1Aa-O7uZKp9hvGvvXT94ctC5CdAPZRKzH8Sfyqs8A&utm_content=2&utm_source=hs_email

Sally Wardprofesseur d'immunologie moléculaire et directrice de l'immunologie translationnelle au Centre d'immunologie du cancer de la faculté de médecine de l'Université de Southampton"Targeting subcellular trafficking pathways to  design antibody-based therapeutics for cancer and autoimmunity"Professors Sally Ward and Raimund Ober have recently relocated their research group from the USA to Southampton. Their interdisciplinary research program is dedicated to the use of protein engineering to develop novel antibody-based therapeutics. The identification in the Ward/Ober laboratory of the Fc receptor, FcRn, as a regulator of IgG levels and transport has resulted in significant interest in targeting FcRn in biopharma. Extensive analyses of FcRn behaviour, including subcellular trafficking studies, have led to collaborations with biopharma to develop several therapeutics that are based on modulating the interactions of IgG with FcRn. For example, one such therapeutic (Efgartigimod) that inhibits FcRn activity has been developed in collaboration with Argenx, and has recently been successfully used in phase 3 trials to treat antibody-mediated autoimmune diseases. "The presentation will cover how a combination of antibody engineering, fluorescence microscopy and mouse disease models have been used to inform the design of therapeutics to modulate the dynamic behavior of antibodies for the treatment of autoimmunity. In particular, the targeting of the MHC Class I-related receptor, FcRn, that recycles and transports IgG to maintain IgG homeostasis will be discussed. The generation of engineered antibody-drug conjugates that are designed to deliver their cytotoxic payload more efficiently to tumor cells will also be presented"

Julie BonnereauPhD student – INSERM U1160, Intestinal Immunity in Inflammation and Cancer - Hôpital Saint Louis, Paris « Targeting the CD39/CD73 adenosinergic pathway in human colorectal cancer increased T cell infiltration and tumor destruction in an autologous coculture model »« The 3IC team works on the intestinal immunity in inflammation and cancer, and more specifically on T cells. The intestine presents a particular immune system, constantly stimulated by exogenous antigens from food, commensal microbiota or pathogens. Specific regulations balance the immune response between tolerance of microbiota and food antigens, and protection against pathogens. This immune homeostasis is crucial and its perturbation are involved in several pathologies. Upon epithelial stress and continuous inflammation, an abnormal proinflammatory immune response can induce autoimmune reactions and chronic inflammation diseases, whereas an excessive tolerant phenotype established an immunosuppressive microenvironment favourable to cancer progression. In this tumor context, an antitumor T cell response is clearly engaged but the upregulation of immunosuppressive markers, like the immune checkpoints, allow the tumor immune escape. Immunotherapies targeting these markers, anti-PD-1 and anti-CTLA-4, were developed but presented a weak efficacy in colorectal cancer (CRC).  New therapeutic strategies are necessary. In this project, we studied the antitumor T cell response involved in human CRC. Based on a prospective cohort, our objectives were to better characterize this response to find new potential target for immunotherapy and test their efficacy in our innovative autologous coculture model. We focused on several different pathways including CD39 and CD73. » Contact IRCM : Laurent GROS

The Colinge Laboratory Cancer Bioinformatics and Systems Biology at IRCM (Cancer Research Institute of Montpellier) is looking for a talented postdoctoral fellow. The microenvironment of cancer cells is known to play an important role in tumor progression and resistance. We are looking for a talented post-doctoral scientist to develop models relating the response to different drugs, e.g. platinum-based, with the microenvironment of lung adenocarcinomas (LUADs). This work will integrate on-going developments to infer the cellular interactions taking place in tumor microenvironments (TMEs), both in single cell transcriptomics and bulk analyses (Cabello et al., 2020; Alame et al., 2020). We aim at establishing quantitative and predictive models of treatment outcome based on data acquired from mouse tumors following different dynamics (rapid/slow growth, spontaneous/acquired resistance, response, etc.). The project involves a consortium of expert laboratories in lung cancer and mouse models thereof, bulk and single cell transcriptomics, animal computer tomography, and 3D-imaging. The postdoc position is funded for 2 years.  More 

Félicitations à Ghita Chabab qui a remporté le prix du public lors de la finale régionale MT180FR "Occitanie-Méditerranée" !!Ghita est financé par le @FRM_officiel et effectue sa thèse à l'IRCM, au sein de l'équipe Immunité et cancer du Dr Nathalie Bonnefoy.

 Antoine Gleizes a reçu le prix de la meilleure présentation orale lors des journées du CECED, association qui a pour objectif de promouvoir les échanges scientifiques entre chercheurs travaillant dans le domaine des cellules épithéliales digestives. Antoine a été récompensé pour son travail sur l'étude du rôle du co-régulateur RIP140 dans la biologie des cellules souches intestinales normales et cancéreuses au sein de l'équipe Signalisation Hormonale et Cancer de l'IRCM.

Publication le 22/03/2021L'équipe "Criblage fonctionnel et ciblage du cancer" recrute un IE débutant pour 1 an sur un projet en collaboration avec l'IRMB et la société MedXCell. La date limite de dépôt des dossiers est le 9 avril à 12h. La description du poste et la procédure de dépôt sont accessibles sur le site https://recrutements.umontpellier.fr/#DETAIL002304

Publication le 19/03/21L’Institut de Recherche en Cancérologie de Montpellier propose un poste d’interface entreactivité de Recherche (40% du temps) et Direction scientifique de la plateforme « ProtéomiqueIdentification et Interactions moléculaires » (PP2I) (60% du temps).PP2I est une plateforme de l’IRCM reliée au Pôle Protéomique de Montpellier (PPM) au seinde BioCampus et intégrée aux réseaux Labex MabImprove et SIRIC Montpellier(https://www.ircm.fr/index.php?pagendx=297). Votre mission sera de maintenir et faireprogresser l’expertise de PP2I dans l’étude des interactions moléculaires par des technologieslabel free (SPR, BLI, QCM…) au sein de la région Occitanie.Parallèlement, vous vous impliquerez dans des projets de recherche en lien avec lesthématiques de l’IRCM et/ou PP2I En savoir plus

The @IRCM_MTP and the @ICM_Montpellier wish to express their profound gratitude to the Mayor, town council and merchants of #Baillargues for their commitment and generous contribution to advancing prostate #Cancer research in the frame of the November event 2020.

Ce prix récompense un chercheur junior pour son travail remarquable en radio-oncologie, physique médicale et / ou radiobiologie. La recherche du Dr Constanzo porte sur le rôle des vésicules extracellulaires dans l’activation du système immunitaire, dans un contexte de Radiothérapie vectorisée des tumeurs à base d’anticorps monoclonaux radiomarqués. Ce projet est conduit au sein de l’équipe dirigée par le Dr. J-P Pouget « Radiobiologie et Radiothérapie Vectorisée » de l’Institut de Recherche en Cancérologie de Montpellier (IRCM, INSERM U1194). En savoir plus : https://www.radres.org/page/2020Awards