Des concepts aux biomarqueurs

et innovations en médecine de précision

19 équipes de recherche,

10 plateformes, 2 biotechs hébergées

Nos outils à la pointe de la technologie,

au service de la recherche contre le cancer

Au coeur d'un campus dédié à la recherche appliquée sur le cancer...

...ET DE MONTPELLIER,

VILLE HISTORIQUEMENT LIÉE A LA RECHERCHE ET L'ENSEIGNEMENT EN MÉDECINE

Les équipes de recherche de l'IRCM
Les équipes de recherche de l'IRCM

L'Institut de Recherche en Cancérologie de Montpellier :
«Ensemble, repoussons les limites»

Actualités

SEMINAIRE EXTERNE IRCM

Professor Generoso BEVILACQUAhttps://orcid.org/0000-0001-8857-2609Department of Translational Research and New Technologies in Medicine, University of Pisa, Italy. "Viral Origin of Breast Cancer"hôte : Andrei TURTOI (IRCM) 
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SEMINAIRE EXTERNE IRCM Mardi 10 juin 14h

Professor Kazuya KABAYAMAInstitute for Radiation Sciences, Osaka University, Japan"Alpha-targeted therapy by regulating the intracellular dynamics of antibody drugs"Professor Kazuya Kabayama leads the Laboratory for Radiation Chemical Biology at Osaka University, where his research bridges chemistry, cellular biology, and nuclear medicine. His primary focus is on developing innovative treatments in radiotherapy, particularly targeted alpha therapy (TAT) using astatine-211 (211At), a promising alpha-emitting radionuclide for the treatment of resistant cancers. Professor Kabayama has contributed significantly to the design and synthesis of 211At-labeled compounds aimed at first-in-human clinical trials. He has also participated in studies exploring 211At-labeled gold nanoparticles, demonstrating their potent antitumor effects. His work plays a key role in advancing the clinical translation of alpha-based radiopharmaceuticals. In parallel, his research investigates molecular interactions involving lipids and glycans, especially in the context of innate immunity and diseases such as cancer and diabetes. His team develops real-time cellular imaging tools to analyze the dynamics of glycolipids and multivalent glycan-receptor interactions at the membrane level. Through a highly interdisciplinary approach combining organic chemistry, radiobiology, and molecular imaging, Professor Kabayama contributes to the advancement of targeted therapies and the fundamental understanding of complex disease mechanisms. His work positions him at the forefront of innovation in both therapeutic and diagnostic strategies in nuclear medicine. host : Jean-Pierre POUGET (IRCM)
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SEMINAIRE EXTERNE MARDI 08 JUILLET

François LEULIERInstitut de Génomique Fonctionnelle de Lyon (IGFL), UMR 5242 CNRS / E.N.S. de Lyon (France)"Microbial Influence on Juvenile Physiology"hôte : Alexandre DJIANE et Jennifer FALCONI (IRCM-Inserm)
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SEMINAIRE EXTERNE JEUDI 16 OCTOBRE

Takahiro ITODEPARTMENT OF BIOSYSTEMS SCIENCELab of Cell Fate Dynamics and Therapeutics Kyoto University, Japan"Metabolic regulation of cell fates in cancer"host : Andrei Turtoï (IRCM)
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CALL FOR NEW GROUP LEADERS @ IRCM

The IRCM is recruiting new group leaders to establish world-class research programs withinan interactive and supportive scientific environment. Applicants demonstrating potentialsynergies with IRCM’s main research topics will be considered for starting an independentteam as soon as January 2027. Projects at the interface of fundamental and clinical research,particularly those focused on the ICM's flagship pathologies, will be given carefulconsideration. We welcome senior team leaders with permanent INSERM / CNRS positionsas well as early-career researchers eligible to ERC, INSERM ATIP-AVENIR and FRM start-upgrants. MORE INFORMATIONS HERE
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Le mot de la Directrice

«Ensemble, repoussons les limites»

«En à peine 20 ans, l'Institut de Recherche en Cancérologie de Montpellier (IRCM U1194) a su hisser sa recherche au meilleur niveau international dans le domaine de la cancérologie fondamentale et appliquée, recherche réalisée en étroite collaboration avec les services cliniques du Centre de Lutte Contre le Cancer de Montpellier (ICM: l’Institut du Cancer de Montpellier ), et des partenaires industriels. Sous la tutelle conjointe de l'Inserm, de l'ICM et de l'Université de Montpellier, l'IRCM rassemble aujourd'hui plus de 240 personnes, chercheurs, cliniciens, techniciens et étudiants, organisés en 16 équipes de recherche qui s'appuient sur des plateaux techniques performants et des services de soutien compétents. Dans un domaine de recherche extrêmement compétitif et en évolution toujours plus rapide, notre plus grand défi est de garder une longueur d’avance. Pour cela nous continuerons à structurer la recherche sur le cancer à Montpellier, à rechercher l’excellence et à accélérer l’innovation et le transfert au patient pour in fine contribuer à vaincre les innombrables formes différentes de cancer. Ensemble, repoussons les limites.»

Nathalie Bonnefoy, Directrice de l'IRCM

Le mot de la Directrice

Principales publications

Tabet I, Candiello E, Fenou L, Velazquez C, Jacot W, Ribeyre C, Sardet C, Theillet C Replication poison treated BRCA1-deficient breast cancers are prone to MRE11 over-resection resulting in single strand DNA accumulation and mitotic catastrophe.. Cancer Research. 2025;in press.

Di Michele M, Attina A, Roux P-F, Laguesse S, Florido J, Houdeville M, Choquet A, Encislai B, Arena G, De Blasio C, Wendling O, Frenois F-X, Papon L, Stuani L, Fuentes M, Jahannault Talignani C, Rousseau M, Guégan J, Buscail Y, Dupré P, Michaud H-A, Rodier G, Bellvert F, Kulyk H, Ferraro Peyret C, Mathieu H, Close P, Rapino F, Chaveroux C, Pirot N, Rubio L, Torro A, Sorg T, Ango F, Hirtz C, Compan V, Lebigot E, Legati A, Ghezzi D, Nguyen L, David A, Sardet C, Lacroix M, Le Cam L E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development. Nat Commun. 2025;16(1):67. doi:10.1038/s41467-024-55444-y

Slaninová V, Heron-Milhavet L, Robin M, Jeanson L, Aissanou A, Kantar D, Tosi D, Bréhélin L, Gongora C, Djiane A The Hippo pathway terminal effector TAZ/WWTR1 mediates oxaliplatin sensitivity in p53 proficient colon cancer cells. BMC Cancer. 2024;24(1):587. doi:10.1186/s12885-024-12316-4

Bruciamacchie M, Garambois V, Vie N, Bessede T, Michaud H-A, Gros L, Bonnefoy N, Robin M, Brager D, Bigot K, Evrard A, Pourquier P, Colinge J, Mathonnet M, Belhabib I, Jean C, Bousquet C, Colombo P-E, Jarlier M, Gongora C, Larbouret C ATR inhibition potentiates FOLFIRINOX cytotoxic effect in models of pancreatic ductal adenocarcinoma by remodelling the tumour microenvironment. Br J Cancer. 2024-11-29. doi:10.1038/s41416-024-02904-3

Desroys du Roure P, Lajoie L, Mallavialle A, Alcaraz L, Mansouri H, Fenou L, Garambois V, Rubio L, David T, Coenon L, Boissière-Michot F, Chateau M-C, Ngo G, Jarlier M, Villalba M, Martineau P, Laurent-Matha V, Roger P, Guiu S, Chardès T, Gros L, Liaudet-Coopman E A novel Fc-engineered cathepsin D-targeting antibody enhances ADCC, triggers tumor-infiltrating NK cell recruitment, and improves treatment with paclitaxel and enzalutamide in triple-negative breast cancer. J Immunother Cancer. 2024;12(1):e007135. doi:10.1136/jitc-2023-007135

Manteaux G, Amsel A, Riquier-Morcant B, Prieto Romero J, Gayte L, Fourneaux B, Larroque M, Gruel N, Quignot C, Jacq S, Pomiès P, Sengenes C, Chibon F, Heuillet M, Bellvert F, Watson S, Firmin N, Riscal R, Linares L A metabolic crosstalk between liposarcoma and muscle sustains tumor growth. Nat Commun. 2024;15(1):7940. doi:10.1038/s41467-024-51827-3

Villemin J-P, Bassaganyas L, Pourquier D, Boissière F, Cabello-Aguilar S, Crapez E, Tanos R, Cornillot E, Turtoi A, Colinge J Inferring ligand-receptor cellular networks from bulk and spatial transcriptomic datasets with BulkSignalR. Nucleic Acids Res. 2023-05-05. doi:10.1093/nar/gkad352

Jacquier V, Gitenay D, Fritsch S, Bonnet S, Gy?rffy B, Jalaguier S, Linares L, Cavaillès V, Teyssier C RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53. Cell Mol Life Sci. 2022;79(5):270. doi:10.1007/s00018-022-04277-3

Pisareva E, Mihalovi?ová L, Pastor B, Kudriavtsev A, Mirandola A, Mazard T, Maus U, Ostermann L, Weinmann-Menke J, Neuberger E, Simon P, Thierry A Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA. Genome Med. 2022;14(1):135. doi:10.1186/s13073-022-01125-8

du Manoir S, Delpech H, Orsetti B, Jacot W, Pirot N, Noel J, Colombo P-E, Sardet C, Theillet C In high-grade ovarian carcinoma, platinum-sensitive tumor recurrence and acquired-resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and SOX2. J Pathol. 2022;257(3):367-378. doi:10.1002/path.5896

Chiavarina B, Costanza B, Ronca R, Blomme A, Rezzola S, Chiodelli P, Giguelay A, Belthier G, Doumont G, Van Simaeys G, Lacroix S, Yokobori T, Erkhem-Ochir B, Balaguer P, Fabbrizio E, Di Valentin E, Detry O, Jerusalem G, Goldman S, Delvenne P, Bellahcène A, Pannequin J, Castronovo V, Turtoi A Metastatic colorectal cancer cells maintain the TGF? program and use TGFBI to fuel angiogenesis. Theranostics. 2021;11(4):1626-1640. doi:10.7150/thno.51507

Relier S, Ripoll J, Guillorit H, Amalric A, Achour C, Boissière F, Vialaret J, Attina A, Debart F, Choquet A, Macari F, Marchand V, Motorin Y, Samalin E, Vasseur J-J, Pannequin J, Aguilo F, Lopez-Crapez E, Hirtz C, Rivals E, Bastide A, David A FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell. 2021-03-20 00:00:00. doi:10.1038/s41467-021-21758-4

Alcaraz L, Mallavialle A, David T, Derocq D, Delolme F, Dieryckx C, Mollevi C, Boissière-Michot F, Huesgen P, Overall C, Tartare-Deckert S, Jacot W, Chardès T, Guiu S, Roger P, Reinheckel T, Moali C, Liaudet-Coopman E A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment. Theranostics. 2021;11(13):6173-6192. doi:10.7150/thno.58254

Pichard A, Marcatili S, Karam J, Constanzo J, Ladjohounlou R, Courteau A, Jarlier M, Bonnefoy N, Patzke S, Stenberg V, Coopman P, Cartron G, Navarro-Teulon I, Repetto-Llamazares A, Heyerdahl H, Dahle J, Bardiès M, Pouget J-P The therapeutic effectiveness of 177Lu-lilotomab in B-cell non-Hodgkin lymphoma involves modulation of G2/M cell cycle arrest. Leukemia. 2020;34(5):1315-1328. doi:10.1038/s41375-019-0677-4

Alame M, Cornillot E, Cacheux V, Tosato G, Four M, Oliveira L, Gofflot S, Delvenne P, Turtoi E, Cabello-Aguilar S, Nishiyama M, Turtoi A, Martineau V, Colinge J The molecular landscape and microenvironment of salivary duct carcinoma reveal new therapeutic opportunities. Theranostics. 2020;10(10):4383-4394. doi:10.7150/thno.42986

Cissé M, Pyrdziak S, Firmin N, Gayte L, Heuillet M, Bellvert F, Fuentes M, Delpech H, Riscal R, Arena G, Chibon F, Le Gellec S, Maran-Gonzalez A, Chateau M-C, Theillet C, Portais J-C, Le Cam L, Linares L Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma. Sci Transl Med. 2020;12(547):eaay2163. doi:10.1126/scitranslmed.aay2163

Ho-Pun-Cheung A, Bazin H, Boissière-Michot F, Mollevi C, Landas E, Bleuse J-P, Chardès T, Prost J-F, Pèlegrin A, Jacot W, Mathis G, Lopez-Crapez E Quantification of HER1, HER2 and HER3 by time-resolved Förster resonance energy transfer in FFPE triple-negative breast cancer samples. Br J Cancer. 2020;122(3):397-404. doi:10.1038/s41416-019-0670-8

Hamyeh M, Bernex F, Larive R, Naldi A, Urbach S, Simony-Lafontaine J, Puech C, Bakhache W, Coopman P, Hendriks W, Freiss G PTPN13 induces cell junction stabilization and inhibits mammary tumor invasiveness. Theranostics. 2020;10(3):1016-1032. doi:10.7150/thno.38537

Bousquet Mur E, Bernardo S, Papon L, Mancini M, Fabbrizio E, Goussard M, Ferrer I, Giry A, Quantin X, Pujol J-L, Calvayrac O, Moll H, Glasson Y, Pirot N, Turtoi A, Cañamero M, Wong K-K, Yarden Y, Casanova E, Soria J-C, Colinge J, Siebel C, Favre G, Paz-Ares L, Maraver A Notch inhibition overcomes resistance to tyrosine kinase inhibitors in EGFR-driven lung adenocarcinoma. J Clin Invest. 2020;130(2):612-624. doi:10.1172/JCI126896

Ashraf Y, Mansouri H, Laurent-Matha V, Alcaraz L, Roger P, Guiu S, Derocq D, Robin G, Michaud H-A, Jarlier M, Pugnière M, Robert B, Puel A, Martin L, Landomiel F, Bourquard T, Achour O, Fruitier-Arnaudin I, Pichard A, Deshayes E, Turtoi A, Poupon A, Boissière-Michot F, Pirot N, Bernex F, Jacot W, du Manoir S, Theillet C, Pouget J-P, Navarro-Teulon I, Bonnefoy N, Pèlegrin A, Chardès T, Martineau P, Liaudet-Coopman E Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies. J Immunother Cancer. 2019;7(1):29. doi:10.1186/s40425-019-0498-z

Perrot I, Michaud H-A, Giraudon-Paoli M, Augier S, Docquier A, Gros L, Courtois R, Jecko D, Becquart O, Rispaud-Blanc H, Gauthier L, Rossi B, Chanteux S, Gourdin N, Amigues B, Roussel A, Bensussan A, Eliaou J-F, Bastid J, Romagné F, Morel Y, Narni-Mancinelli E, Vivier E, Paturel C, Bonnefoy N Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies. Cell Rep. 2019;27(8):2411-2425.e9. doi:10.1016/j.celrep.2019.04.091

Constanzo J, Parach A, David T, Karam J, Bruchertseifer F, Morgenstern A, Jarlier M, Bardiès M, Deshayes E, Gudin-de-vallerin A, Boissière-Michot F, Lopez-Crapez E, Pouget J-P MHC-I-driven anti-tumor immunity counterbalances low absorbed doses of targeted radionuclide therapy. in press.


© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés