Research
Signaling of tumor invasion : P. Coopman

RESEARCH TOPICS

Understanding of the signaling pathways that govern tumor formation and progression is confronted with the complexity, balance and cross-talk of pro- and anti-oncogenic signaling pathways. The major aim of our team is to unravel signaling pathways involved in the positive (oncogenes) or negative regulation (tumor suppressor genes) of tumor formation and progression (invasion & metastasis) and identify novel biomarkers and therapeutic targets. Our studies initially focused on breast cancer but are, dependent on recent observations, also extended to ovarian and lung cancer. Breast cancer is the most common invasive cancer in women and metastatic spread is the main cause of treatment failure and mortality. In breast cancer, we are interested in the signaling pathways controlled by the Syk protein tyrosine kinase and the PTPN13 protein tyrosine phosphatase for which we have established for the first time their negative effect on the formation and invasion of mammary tumors (tumor suppressor role). Our team and others have found a positive correlation between decreased expression and increased metastatic capacity, as well as decreased survival in breast cancer patients; findings that were corroborated in a growing number of others carcinomas. Among these carcinomas, our team is interested in lung cancer, which is the leading cause of cancer deaths in the world. Our research focuses on the KRAS oncogene, known to have a positive effect on the development, progression and chemoresistance of lung cancers, and its possible connections with the pathways controlled by Syk and PTPN13. Finally, we are also studying the molecular mechanisms of melanoma resistance to targeted therapies. In collaboration with systems biologists, we reconstruct intracellular signaling networks from our proteomics data and model the molecular and cellular responses to new anti-cancer treatments.

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MAIN PUBLICATIONS

Buffard M, Naldi A, Freiss G, Deckert M, Radulescu O, Coopman P, Larive R Comparison of SYK Signaling Networks Reveals the Potential Molecular Determinants of Its Tumor-Promoting and Suppressing Functions. Biomolecules. 2021;11(2). doi:10.3390/biom11020308

Hamyeh M, Bernex F, Larive R, Naldi A, Urbach S, Simony-Lafontaine J, Puech C, Bakhache W, Coopman P, Hendriks W, Freiss G PTPN13 induces cell junction stabilization and inhibits mammary tumor invasiveness. Theranostics. 2020;10(3):1016-1032. doi:10.7150/thno.38537

Béganton B, Coyaud E, Laurent E, Mangé A, Jacquemetton J, Le Romancer M, Raught B, Solassol J Proximal Protein Interaction Landscape of RAS Paralogs. Cancers. 2020;12(11):3326. doi:10.3390/cancers12113326

Mcheik S, Aptecar L, Coopman P, D'Hondt V, Freiss G Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer. Biomolecules. 2020;10(12). doi:10.3390/biom10121659

Kassouf T, Larive R, Morel A, Urbach S, Bettache N, Marcial Medina M, Mèrezègue F, Freiss G, Peter M, Boissière-Michot F, Solassol J, Montcourrier P, Coopman P The Syk Kinase Promotes Mammary Epithelial Integrity and Inhibits Breast Cancer Invasion by Stabilizing the E-Cadherin/Catenin Complex. Cancers (Basel). 2019;11(12). doi:10.3390/cancers11121974

Béganton B, Solassol I, Mangé A, Solassol J Protein interactions study through proximity-labeling. Expert Rev Proteomics. Jul 04, 2019. doi:10.1080/14789450.2019.1638769

Buffard M, Naldi A, Radulescu O, Coopman P, Larive R, Freiss G Network Reconstruction and Significant Pathway Extraction Using Phosphoproteomic Data from Cancer Cells. Proteomics. 2019;19(21-22):e1800450. doi:10.1002/pmic.201800450

Mangé A, Coyaud E, Desmetz C, Coopman P, Raught B, Solassol J FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer. Theranostics. 2019;9(23):7003-7015. doi:10.7150/thno.35561

Naldi A, Larive R, Czerwinska U, Urbach S, Montcourrier P, Roy C, Solassol J, Freiss G, Coopman P, Radulescu O Reconstruction and signal propagation analysis of the Syk signaling network in breast cancer cells. PLoS Comput. Biol.. 2017;13(3):e1005432. doi:10.1371/journal.pcbi.1005432

D'Hondt V, Lacroix-Triki M, Jarlier M, Puech C, Coopman P, Katsaros D, Freiss G High PTPN13 expression in high grade serous ovarian carcinoma is associated with a better patient outcome. Oncotarget. 2017;8(56):95662-95673. doi:10.18632/oncotarget.21175


Team

Team Leader : Peter Coopman
 

Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5

Tél. 33 (0)4 67 61 24 32
Fax 33 (0)4 67 61 37 87

peter.coopman@inserm.fr

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partners / funding

   


© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés