Research
Genetic and phenotypic plasticity of cancer : C. Sardet

activities

The INSERM team “Genetic and Phenotypic Plasticity of Cancer” was co-created in 2015 by C Sardet and C. Theillet. The team has close links with clinical oncology (Pr W Jacot) and oncological surgery (Pr PE Colombo) at the Montpellier Cancer Institute (ICM / Centre de Lutte Contre le Cancer). Our projects are focused on Triple-Negative Breast Cancer (TNBC) and High-Grade Ovarian Cancer (HGOC). They intend to identify and target the “Achille’s heels” and various adaptative strategies (DNA repair, metabolism, signaling) of these tumors and of their treatment-resistant cell populations responsible for recurrence. 

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MAIN PUBLICATIONS

Tabet I, Candiello E, Fenou L, Velazquez C, Jacot W, Ribeyre C, Sardet C, Theillet C Replication poison treated BRCA1-deficient breast cancers are prone to MRE11 over-resection resulting in single strand DNA accumulation and mitotic catastrophe.. Cancer Research. 2025;in press.

Orhan E, Velazquez C, Tabet I, Fenou L, Rodier G, Orsetti B, Jacot W, Sardet C, Theillet C CDK inhibition results in pharmacologic BRCAness increasing sensitivity to olaparib in BRCA1-WT and olaparib resistant in Triple Negative Breast Cancer. Cancer Lett. 2024;589. doi:10.1016/j.canlet.2024.216820

Modi S, Jacot W, Yamashita T, Sohn J, Vidal M, Tokunaga E, Tsurutani J, Ueno N, Prat A, Chae Y, Lee K, Niikura N, Park Y, Xu B, Wang X, Gil-Gil M, Li W, Pierga J-Y, Im S-A, Moore H, Rugo H, Yerushalmi R, Zagouri F, Gombos A, Kim S-B, Liu Q, Luo T, Saura C, Schmid P, Sun T, Gambhire D, Yung L, Wang Y, Singh J, Vitazka P, Meinhardt G, Harbeck N, Cameron D Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer. N Engl J Med. 2022;387(1):9-20. doi:10.1056/NEJMoa2203690

du Manoir S, Delpech H, Orsetti B, Jacot W, Pirot N, Noel J, Colombo P-E, Sardet C, Theillet C In high-grade ovarian carcinoma, platinum-sensitive tumor recurrence and acquired-resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and SOX2. J Pathol. 2022;257(3):367-378. doi:10.1002/path.5896

Lacroix M, Rodier G, Kirsh O, Delpech H, Seyran B, Gayte L, Casas F, Pessemesse L, Heuillet M, Bellvert F, Portais J-C, Berthet C, Bernex F, Brivet M, Boutron A, Le Cam L, Sardet C E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity. Proc. Natl. Acad. Sci. U.S.A.. 2016;113(39):10998-11003. doi:10.1073/pnas.1602754113


team

Team Leader :

Claude Sardet
 

Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5

 

 

 


 

Tél. : 33 (0)4 67 61 37 66
Fax : 33 (0)4 67 61 30 41

claude.sardet@inserm.fr

  

partners / funding

              


© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés