We have established several mice and cellular models in which each of the genes encoding these proteins has been either inactivated or mutated. These models will allow us, through a combination of molecular, cellular and organismal approaches, to address several key questions: (1) how these proteins do influence chromatin and nuclear organization? (2) What is the link between chromatin/nuclear organization and cellular functions? (3) What are the partners involved in these functions and (4) How mis-regulation of this level of information can lead a normal cell to transform into a cancerous cell.
Our results will provide new insights into the understanding of the molecular mechanisms underlying the establishment and/or the progression of numerous cancers of epigenetic origins and ultimately will allow us to propose new therapeutic strategies specifically targeting chromatin regulators.
Located in the Parc Euromédecine, the Institut de Recherche en Cancérologie de Montpellier (U1194) is located on the Val d'Aurelle Campus (ICM, Institut régional du Cancer Montpellier/ Val d'Aurelle).
U1194 Research Centre supported by Inserm, the University of Montpellier and the Institut du Cancer de Montpellier (ICM)
Institut de Recherche en Cancérologie de