Research
Immunity and cancer : N. Bonnefoy

RESEARCH TOPICS

Over the past decade, the focus of cancer treatment has shifted from the tumor to the host, with the development of various forms of immune-based therapies that mobilize the immune system to promote or restore an effective anti-tumor immune response. A better understanding of the relationships between cancer cells and cells of the immune system is mandatory to further improve patient’s outcome. As illustrated by our recent work on the CD39/CD73/Adenosine pathway (Perrot I et al. 2019), through a deep and comprehensive analysis of tumor immune microenvironment, the Immunity & Cancer team in close collaboration with clinicians and industrial partners, aims at deciphering immunosuppressive molecular and cellular mechanisms that contribute to tumor escape from immune surveillance and at offering proof-of-concept for new targets and new immune based combined therapies to improve response to conventional therapies such as targeted therapies or radio- and chemo-therapies.

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Figure : Tumor cell recognized by a cytotoxic lymphocyte

MAIN PUBLICATIONS

Perrot I, Michaud H-A, Giraudon-Paoli M, Augier S, Docquier A, Gros L, Courtois R, Jecko D, Becquart O, Rispaud-Blanc H, Gauthier L, Rossi B, Chanteux S, Gourdin N, Amigues B, Roussel A, Bensussan A, Eliaou J-F, Bastid J, Romagné F, Morel Y, Narni-Mancinelli E, Vivier E, Paturel C, Bonnefoy N Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies. Cell Rep. 2019;27(8):2411-2425.e9. doi:10.1016/j.celrep.2019.04.091

Barjon C, Michaud H-A, Fages A, Dejou C, Zampieri A, They L, Gennetier A, Sanchez F, Gros L, Eliaou J-F, Bonnefoy N, Lafont V IL-21 promotes the development of a CD73-positive V?9V?2 T cell regulatory population. Oncoimmunology. 2017;7(1):e1379642. doi:10.1080/2162402X.2017.1379642


Team

Team Leader  : Nathalie Bonnefoy
 

Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5

Tél. : 33 (0)4 67 61 24 40
Fax : 33 (0)4 67 61 37 87
nathalie.bonnefoy@inserm.fr

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partners / funding

          


© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés