Research
Cancer bioinformatics and systems biology : J. Colinge

Cancer bioinformatics and systems biology

SUMMARY

Our current research falls in three axes.

 

Axis 1: We infer biological networks by integrating several omics with reference intra- (signaling, transcription) and inter-cell (tumor microenvironment) interactions to find active functional modules. We apply such methods to different rare, aggressive tumor cohorts or metastases, which display resistance to frontline therapy. We try to unravel resistance mechanisms and find targets able to break resistance.

 

Axis 2: Network inference from perturbation experiments. We set up different projects where the detailed, quantitative and predictive analysis of a chosen biological network is required. Extending modular response analysis methods (Kholodenko), we infer weighted, directed networks.

 

Axis 3: Computational proteomics. Main focus at the moment is the development (with clinical partners) of a an innovative experiment/computational framework to determine protein turnover parameters in biological fluids in patients and in vivo. We have obtained very promising results in the CSF and plasma introducing a new mathematical model integrated with MS data processing and bioinformatics pipelines. We want to explore a new class of biomarkers related to abnormal clearance rates or passage across biological barriers such as blood-brain in disease, e.g. Alzheimer disease

                                 More                              

Publications

Alame M, Cornillot E, Cacheux V, Tosato G, Four M, Oliveira L, Gofflot S, Delvenne P, Turtoi E, Cabello-Aguilar S, Nishiyama M, Turtoi A, Martineau V, Colinge J The molecular landscape and microenvironment of salivary duct carcinoma reveal new therapeutic opportunities. 2020;10(10):4383-4394. doi:10.7150/thno.42986

Sobecki M, Mrouj K, Colinge J, Gerbe F, Jay P, Krasinska L, Dulic V, Fisher D Cell-Cycle Regulation Accounts for Variability in Ki-67 Expression Levels. Cancer Res.. 2017;77(10):2722-2734. doi:10.1158/0008-5472.CAN-16-0707

Muellner M, Mair B, Ibrahim Y, Kerzendorfer C, Lechtermann H, Trefzer C, Klepsch F, Muller A, Leitner E, Macho-Maschler S, Superti-Furga G, Bennett K, Baselga J, Rix U, Kubicek S, Colinge J, Serra V, Nijman S Targeting a cell state common to triple-negative breast cancers. Molecular systems biology. 2015;11. doi:10.15252/msb.20145664

Blomen V, Majek P, Jae L, Bigenzahn J, Nieuwenhuis J, Staring J, Sacco R, van Diemen F, Olk N, Stukalov A, Marceau C, Janssen H, Carette J, Bennett K, Colinge J, Superti-Furga G, Brummelkamp T Gene essentiality and synthetic lethality in haploid human cells. Science. Oct 15 2015. doi:10.1126/science.aac7557


Team

Team Leader  : Jacques Colinge
 

Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5


 

Tél. : 33 (0)4 67 61 23 92
Fax : 33 (0)4 67 61 37 87
jacques.colinge@inserm.fr

 

partners / funding


© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés