Cancer bioinformatics and systems biology : J. Colinge

Cancer bioinformatics and systems biology


Our current research is divided into two major and related areas. Firstly, the development and deployment of methods for inferring intracellular biological networks (signaling, transcription), as well as intercellular networks involving the microenvironment. Then, through collaborations, we apply these methods to the study of specific tumor cohorts. Our objectives are generally to identify active functional modules, resistance mechanisms or potential therapeutic targets. A majority of our projects involve space and single-cell biology.

We are also developing various mathematical models for computational proteomics, the study of circulating DNA, or the nanomechanics (rigidity) of tumors.



Borg J-P, Colinge J, Ravel P Modular response analysis reformulated as a multilinear regression problem. Bioinformatics. 2023-04-06. doi:10.1093/bioinformatics/btad166

Villemin J-P, Bassaganyas L, Pourquier D, Boissière F, Cabello-Aguilar S, Crapez E, Tanos R, Cornillot E, Turtoi A, Colinge J Inferring ligand-receptor cellular networks from bulk and spatial transcriptomic datasets with BulkSignalR. Nucleic Acids Res. 2023-05-05. doi:10.1093/nar/gkad352

Giguelay A, Turtoi E, Khelaf L, Tosato G, Dadi I, Chastel T, Poul M-A, Pratlong M, Nicolescu S, Severac D, Adenis A, Sgarbura O, Carrère S, Rouanet P, Ychou M, Pourquier D, Colombo P-E, Turtoi A, Colinge J The landscape of cancer-associated fibroblasts in colorectal cancer liver metastases. Theranostics. 2022;12(17):7624-7639. doi:10.7150/thno.72853

Tosato G, Rivière B, Valats J-C, Debourdeau A, Flori N, Pourquier D, Fabre J-M, Assenat E, Colinge J, Turtoi A Detection of soluble biomarkers of pancreatic cancer in endoscopic ultrasound-guided fine-needle aspiration samples. Endoscopy. 2022;54(5):503-508. doi:10.1055/a-1550-2503

Cabello-Aguilar S, Alame M, Kon-Sun-Tack F, Fau C, Lacroix M, Colinge J SingleCellSignalR: inference of intercellular networks from single-cell transcriptomics. Nucleic Acids Res.. Mar 20, 2020. doi:10.1093/nar/gkaa183


Team Leader  : Jacques Colinge

Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5


Tél. : 33 (0)4 67 61 23 92
Fax : 33 (0)4 67 61 37 87


partners / funding

© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés