Research
Epigenetic Regulation and Cancer : E. Julien

activities

Our group investigates the epigenetic mechanisms mediated by the KMT5 methyltransferases family in the context of cancer and its resistance to therapy.

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MAIN PUBLICATIONS

Herviou L, Ovejero S, Izard F, Karmous-Gadacha O, Gourzones C, Bellanger C, De Smedt E, Ma A, Vincent L, Cartron G, Jin J, De Bruyne E, Grimaud C, Julien E, Moreaux J Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma. Clin Epigenet. 2021;13(1):174. doi:10.1186/s13148-021-01160-z

Zouaz A, Fernando C, Perez Y, Sardet C, Julien E, Grimaud C Cell-cycle regulation of non-enzymatic functions of the Drosophila methyltransferase PR-Set7. Nucleic Acids Res.. 2018;46(6):2834-2849. doi:10.1093/nar/gky034

Brustel J, Kirstein N, Izard F, Grimaud C, Prorok P, Cayrou C, Schotta G, Abdelsamie A, Déjardin J, Méchali M, Baldacci G, Sardet C, Cadoret J-C, Schepers A, Julien E Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication. EMBO J.. 2017;36(18):2726-2741. doi:10.15252/embj.201796541

Tardat M, Brustel J, Kirsh O, Lefevbre C, Callanan M, Sardet C, Julien E The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells. Nat. Cell Biol.. 2010;12(11):1086-1093. doi:10.1038/ncb2113


Teams

Team Leader  : Eric Julien
 

Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5


 

Tél. : 33 (0)4 11 28 31 30
eric.julien@inserm.f

Partners / Funding

       


© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés