Epigenetic Regulation and Cancer : E. Julien


Our group is interested in the molecular mechanisms that govern the organization of the genome into chromatin and that lead to cancer. In recent years, we have undertaken the identification and molecular characterization of new signaling pathways in the control of genome activity and organization during the cell cycle. These signaling pathways involve the lysine methyltransferases responsible for the methylation of the lysine 20 at the N-terminal tail of the histone H4. By developing cutting-edge approaches in genomics and proteomics in mammalian and Drosophila models, our current projects aim to (i) better understand how these enzymes and their substrates work and (ii) determine how their inhibition by chemical molecules can lead to innovative therapeutic approaches against cancer.


Herviou L, Ovejero S, Izard F, Karmous-Gadacha O, Gourzones C, Bellanger C, De Smedt E, Ma A, Vincent L, Cartron G, Jin J, De Bruyne E, Grimaud C, Julien E, Moreaux J Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma. Clin Epigenet. 2021;13(1):174. doi:10.1186/s13148-021-01160-z

Zouaz A, Fernando C, Perez Y, Sardet C, Julien E, Grimaud C Cell-cycle regulation of non-enzymatic functions of the Drosophila methyltransferase PR-Set7. Nucleic Acids Res.. 2018;46(6):2834-2849. doi:10.1093/nar/gky034

Brustel J, Kirstein N, Izard F, Grimaud C, Prorok P, Cayrou C, Schotta G, Abdelsamie A, Déjardin J, Méchali M, Baldacci G, Sardet C, Cadoret J-C, Schepers A, Julien E Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication. EMBO J.. 2017;36(18):2726-2741. doi:10.15252/embj.201796541

Tardat M, Brustel J, Kirsh O, Lefevbre C, Callanan M, Sardet C, Julien E The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells. Nat. Cell Biol.. 2010;12(11):1086-1093. doi:10.1038/ncb2113


Team Leader  : Eric Julien

Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5


Tél. : 33 (0)4 67 61 45 14
Fax : 33 (0)4 67 61 37 87

Partners / Funding


© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés