Biomarkers for Precision Oncology : A. Thierry


Our team’s objective is to discover and use predictive and prognostic biomarkers for a personalized medicine in digestive oncology. The team is composed of researchers developing fundamental and translational projects and clinicians involved in integrative and clinically relevant research.

Our project integrates interdisciplinary skills including fundamental research on signaling pathways, molecular biology, tumor microenvironment studies, imaging biomarker research, biostatistics and clinical research. These skills enable the development of innovative translational research programs on digestive cancers.

We are particularly interested in the analysis of circulating cell free DNA and microRNA, protein dimerization profiles, the oncogenic Wnt/β-Catenin signaling pathway, and new predictive medical imaging markers. An additional asset is the integration of methodological research in biostatistics for biomarker evaluation. A particular effort is devoted to the expression of new molecular and genetic markers in liquid and solid biopsies of human tumors and tissues.

In accordance with the research program focused on colorectal cancer and conducted in close collaboration with the Integrated Cancer Research Site "SIRIC Montpellier Cancer", we are committed to establishing new links between basic research and clinical needs, in order to significantly improve medical practices related to digestive cancers.


Al Amir Dache Z, Otandault A, Tanos R, Pastor B, Meddeb R, Sanchez C, Arena G, Lasorsa L, Bennett A, Grange T, El Messaoudi S, Mazard T, Thierry A Blood contains circulating cell-free respiratory competent mitochondria. FASEB J.. Jan 19, 2020. doi:10.1096/fj.201901917RR

Prévostel C, Blache P The dose-dependent effect of SOX9 and its incidence in colorectal cancer. Eur. J. Cancer. 2017;86. doi:10.1016/j.ejca.2017.08.037

Thierry A, El Messaoudi S, Mollevi C, Raoul J, Guimbaud R, Pezet D, Artru P, Assenat E, Borg C, Mathonnet M, De La Fouchardière C, Gavoille C, Fiess C, Auzemery B, Meddeb R, Lopez-Crapez E, Sanchez C, Pastor B, Ychou M Clinical utility of circulating DNA analysis for rapid detection of actionable mutations to select metastatic colorectal patients for anti-EGFR treatment. Ann. Oncol.. 2017;28(9):2149-2159. doi:10.1093/annonc/mdx330

Thierry A, El Messaoudi S, Gahan P, Anker P, Stroun M Origins, structures, and functions of circulating DNA in oncology. Cancer Metastasis Rev.. 2016;35(3):347-376. doi:10.1007/s10555-016-9629-x

Thierry A, Mouliere F, El Messaoudi S, Mollevi C, Lopez-Crapez E, Rolet F, Gillet B, Gongora C, Dechelotte P, Robert B, Del Rio M, Lamy P, Bibeau F, Nouaille M, Loriot V, Jarrousse A, Molina F, Mathonnet M, Pezet D, Ychou M Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA. Nature medicine. 2014;20. doi:10.1038/nm.3511


Team Leader  Alain Thierry


Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5

Tél. : 33 (0)4 67 61 30 66 / 06 63 82 19 94

Partners / Funding

© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés