News
Seminar

Sébastien PAPOT

Institut de Chimie des Milieux  Matériaux de Poitiers (IC2MP)-ULR CNRS 7285

Professeur des Universités, Responsable de l'Equipe OrgaSynth

" Targeting the Tumor Microenvironment for Cancer Therapy and Diagnosis"

host : Eric Julien (IRCM)

Noboru MIZUSHIMA

Tokyo University (Japan)

"intracellular degradation and quality control by autophagy"

host: Sophie Pattingre (IRCM)

Autophagy is an intracellular degradation system conserved in many eukaryotes. In the process of autophagy, a portion of the cytoplasm is surrounded by autophagosomes and then delivered to lysosomes for degradation. Studies on the molecular mechanism and physiological function of autophagy have made remarkable progress over the past 20 years since the landmark genetic studies in yeast by Dr. Ohsumi and other groups. In this seminar, I will summarize the current status of autophagy research, including methodology, and discuss some recent topics on autophagosome-lysosome fusion, selective degradation of mitochondria by autophagy, and the reversibility of cellular dysfunction caused by autophagy defects.

Thomas DAUBON

Institut de Biochimie et Génétique Cellulaires, UMR 5095 CNRS Université de Bordeaux

"The PacMan effect : when glioblastoma cells eat myelin to invade the brain"

host : Julie Pannequin (IGF) / Laurent Le Cam (IRCM)

Arnaud BLOMME

Laboratory of Metabolic Regulation, GIGA-Research Institute, University of Liège, Belgique

"Targeting mTORC2-dependent metabolic vulnerabilities in lung cancer"

hôte: Andrei Turtoi (IRCM-Inserm)

Thierry DUBOIS

Institut Curie – Centre de Recherche, Département Recherche Translationnelle & CNRS UMR144  

Groupe « Biologie du Cancer du Sein »

“Protein arginine methyltransferases (PRMTs) in triple-negative breast cancer: potential targets and functional studies”

host : Eric JULIEN (IRCM)

Adélaïde RAGUIN

Institute For Computational Cell Biology

Heinrich-Heine University

Dusseldorf (Germany)

"Computational modeling of gene expression and its regulation : an approach based on stochastic simulations and bioinformatics"

host : Alexandre DAVID (IRCM-Inserm)

Nathalie LABARRIERE

INCIT, UMR1302 InsermHead of Team « anti-tumor immunosurveillance and Immunotherapy »IRS2, 22 boulevard Benoni Goullin44200 Nantes – France

"Optimizing T-cells for adoptive cell transfer approaches in melanoma"

host : Céline Gongora (IRCM-Inserm)

 Lluis Fajas Coll

Center for Integrative Genomics, CIG / UNIL Sorge
CH1015 Lausanne Switzerland

"Highway to hell or stairway to heaven: The CDK4 paradox in triple negative breast cancer"

contact : Claude Sardet (IRCM)

 Lluis Fajas Coll

Center for Integrative Genomics, CIG / UNIL Sorge
CH1015 Lausanne Switzerland

"Highway to hell or stairway to heaven: The CDK4 paradox in triple negative breast cancer"

contact : Claude Sardet (IRCM)

Charline OGIER, PhD

Centre de Recherche en Cancérologie de Toulouse (CRCT)-UMR 1037
 

"Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6)"

contact : Christel Larbouret (Inserm-IRCM)

The fibroblastic stroma comprises most of pancreatic adenocarcinoma mass and is remarkably devoid of functional blood vessels leaving an unresolved question of how pancreatic cancer cells obtain their essential metabolites and especially water-insoluble lipids. Contrary to the previously held assumption that cancer cells uptake lipids directly from the interstitial fluid, we have found a critical role for cancer-associated fibroblasts (CAFs) to obtain and transfer blood-borne lipid particles to cancer cells via trogocytosis, a process of “nibbling” of plasma membranes between two cells engaged in synapse-like membrane contacts. Whereas trogocytosis has been described in normal development, the biochemical and signaling regulators of trogocytosis between CAFs and PDAC cells have not been defined. We determined that CAF membrane trogocytosis is triggered by externalized phosphatidylserine (PtdSer), and blockade of PtdSer in vitro transiently deters trogocytic uptake of CAF membranes. We have also discovered a phospholipid scramblase anoctamin 6 (ANO6) expressed in CAFs as the essential trogocytosis regulator to promote cancer cell survival. Mechanistically, CAF-cancer cell membrane contacts induce cytosolic calcium influx via Orai channels, which activates ANO6 and results in phosphatidylserine exposure on CAFs. As a promising therapy target, ANO6 protein is highly expressed in PDAC tumor mass in cancer cells, endothelial cells and CAFs and is a negative prognostic biomarker for survival. Depletion of ANO6 in co-implanted CAFs dramatically reduced the growth of orthotopic pancreatic tumor grafts. Furthermore, pharmacologic inhibitors of ANO6 with clinically available antibiotics niclosamide or clofazimine potently blocked cholesterol uptake in vivo by PDAC cells. 

Docteur Renaud LESOURNE

Institut Toulousain des Maladies Infectieuses et Inflammatoires

" Signaling modulation of immune checkpoints in T cells in normal and autoimmune contexts "

contact : M.A. Poul (IRCM)

Vincent Muczynski

Director of Biology, NovalGen Ltd  / Research Fellow, University College London – Cancer Institut

"Next-generation bispecific T cell engagers with built-in autoregulation to prevent treatment-related adverse events in adoptive T cell immunotherapies."

contact : P. Martineau (IRCM)