Research
Functionnal screening and targeting in cancer : P. Martineau

RESEARCH TOPICS

The team is dedicated to the development of innovative antibody-based biological molecules with novel activities for biosensors and patient treatment. In particular, three strongly linked axes are developed:

  - Structure-function-activity studies of antibodies with the main objective of designing and building synthetic optimized human antibody libraries

  - The use of these antibodies as biosensor tools for the analysis and study of proteins in the cell, particularly with regard to post-translational modifications

  - The development of innovative antibodies with improved profiles for tumor targeting by harnessing the specificities of the tumor cell and its microenvironment

The approaches developed within the team are available for external academic or industrial teams through the genAc platform, which proposes on a collaborative basis the development of human antibodies for in vitro, preclinical and clinical applications.

 

                                                                                   More

MAIN PUBLICATIONS

Mas S, Torro A, Bec N, Erschov G, Gongora C, Larroque C, Martineau P, de Juan A, Marco S Use of physiological information based on grayscale images to improve mass spectrometry imaging data analysis from biological tissues. Anal. Chim. Acta. 2019;1074. doi:10.1016/j.aca.2019.04.074

Leconet W, Chentouf M, du Manoir S, Chevalier C, Sirvent A, Aït-Arsa I, Busson M, Jarlier M, Radosevic-Robin N, Theillet C, Chalbos D, Pasquet J-M, Pèlegrin A, Larbouret C, Robert B Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis. Clin Cancer Res. 2017;23(11):2806-2816. doi:10.1158/1078-0432.CCR-16-1316

Del Rio M, Mollevi C, Bibeau F, Vie N, Selves J, Emile J, Roger P, Gongora C, Robert J, Tubiana-Mathieu N, Ychou M, Martineau P Molecular subtypes of metastatic colorectal cancer are associated with patient response to irinotecan-based therapies. 2017;76. doi:10.1016/j.ejca.2017.02.003

Robin G, Sato Y, Desplancq D, Rochel N, Weiss E, Martineau P Restricted diversity of antigen binding residues of antibodies revealed by computational alanine scanning of 227 antibody-antigen complexes. Journal of molecular biology. Aug 28 2014. doi:10.1016/j.jmb.2014.08.013

Mazuc E, Guglielmi L, Bec N, Parez V, Hahn C, Mollevi C, Parrinello H, Desvignes J, Larroque C, Jupp R, Dariavach P, Martineau P In-cell intrabody selection from a diverse human library identifies c12orf4 protein as a new player in rodent mast cell degranulation. 2014;9. doi:10.1371/journal.pone.0104998


TEAM

 

Team Leader : Pierre Martineau

Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5

Tél. 33 (0)4 67 61 37 43
Fax 33 (0)4 67 61 37 87
pierre.martineau@inserm.fr

Discover the team

 

PARTNERS / FUNDINGS

            


© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés