Research
Functional screening and targeting in cancer : P. Martineau

RESEARCH TOPICS

The team is dedicated to the development of innovative antibody-based biological molecules with novel activities for biosensors and patient treatment. In particular, three strongly linked axes are developed:

  - Structure-function-activity studies of antibodies with the main objective of designing and building synthetic optimized human antibody libraries

  - The use of these antibodies as biosensor tools for the analysis and study of proteins in the cell, particularly with regard to post-translational modifications

  - The development of innovative antibodies with improved profiles for tumor targeting by harnessing the specificities of the tumor cell and its microenvironment

The approaches developed within the team are available for external academic or industrial teams through the genAc platform, which proposes on a collaborative basis the development of human antibodies for in vitro, preclinical and clinical applications.

 

                                                                                   More

MAIN PUBLICATIONS

Colin F, Schauer K, Hamiche A, Martineau P, Borg J-P, Bednar J, Bertolin G, Camoin L, Collette Y, Dimitrov S, Fournier I, Hyenne V, Mendoza-Parra M, Morelli X, Rondé P, Sumara I, Tramier M, Schultz P, Goetz J The NANOTUMOR consortium - Towards the Tumor Cell Atlas. Biol Cell. 2021-02-07. doi:10.1111/boc.202000135

Mairaville C, Martineau P Antibody Identification for Antigen Detection in Formalin-Fixed Paraffin-Embedded Tissue Using Phage Display and Naïve Libraries. Antibodies (Basel). 2021;10(1). doi:10.3390/antib10010004

Chauvin M, Garambois V, Choblet S, Colombo P-E, Chentouf M, Gros L, De Brauwere D-P, Dumas K, Robert B, Jarlier M, Martineau P, Navarro-Teulon I, Pépin D, Chardès T, Pèlegrin A Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival. Int J Oncol. 2021;59(1):43. doi:10.3892/ijo.2021.5223

Chauvin M, Garambois V, Colombo P-E, Chentouf M, Gros L, Brouillet J-P, Robert B, Jarlier M, Dumas K, Martineau P, Navarro-Teulon I, Pépin D, Chardès T, Pèlegrin A Anti-Müllerian hormone (AMH) autocrine signaling promotes survival and proliferation of ovarian cancer cells. Sci Rep. 2021;11(1):2231. doi:10.1038/s41598-021-81819-y

Mangeat T, Gracia M, Martineau P, Robert B [Strategies of tumor-pecific targeting based on the antigenic tumor specificities and the tumor microenvironment characteristics]. Med Sci (Paris). 2020;36 Hors série n° 1. doi:10.1051/medsci/2020194


TEAM

 

Team Leader : Pierre Martineau

Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5

Tél. 33 (0)4 67 61 37 43
Fax 33 (0)4 67 61 37 87
pierre.martineau@inserm.fr

Discover the team

 

PARTNERS / FUNDINGS

            


© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés