Epithelial Growth and Cancer : A. Djiane


In healthy tissues, cell behaviours such as proliferation and adhesion are tightly controlled, ensuring the harmonious growth of tissues and organs. This control is achieved through cellular interactions and short- and long-distance exchanges of information that must then be integrated. Invariably, cancer cells adapt and escape these strict regulations to proliferate and invade surrounding or distant tissues. Using complementary approaches and experimental models, the 'Epithelial growth and cancer' team is seeking to understand how short- and long-distance signalling is integrated in epithelial cells and how their alterations contribute to tumour development. More specifically, we are studying

1. the role of the Hippo tumour suppressor signalling pathway, and how it is regulated

2. cell competition and its influence on tissue and tumour composition

3. interactions between the tumour and the body, particularly during cachexia.



Logeay R, Géminard C, Lassus P, Rodríguez-Vázquez M, Kantar D, Fischer B, Bray S, Colinge J, Djiane A Mechanisms underlying the cooperation between loss of epithelial polarity and Notch signaling during neoplastic growth in Drosophila. Development. 2022-01-10. doi:10.1242/dev.200110

Kantar D, Mur E, Mancini M, Slaninova V, Salah Y, Costa L, Forest E, Lassus P, Géminard C, Boissičre-Michot F, Orsetti B, Theillet C, Colinge J, Benistant C, Maraver A, Heron-Milhavet L, Djiane A MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis. Sci Rep. 2021;11(1):5752. doi:10.1038/s41598-021-85056-1

Forest E, Logeay R, Géminard C, Kantar D, Frayssinoux F, Heron-Milhavet L, Djiane A The apical scaffold big bang binds to spectrins and regulates the growth of Drosophila melanogaster wing discs. J. Cell Biol.. 2018;217(3):1047-1062. doi:10.1083/jcb.201705107

Coopman P, Djiane A Adherens Junction and E-Cadherin complex regulation by epithelial polarity. Cellular and molecular life sciences : CMLS. May 5 2016. doi:10.1007/s00018-016-2260-8

Zaessinger S, Zhou Y, Bray S, Tapon N, Djiane A Drosophila MAGI interacts with RASSF8 to regulate E-Cadherin-based adherens junctions in the developing eye. Development. 2015;142. doi:10.1242/dev.116277


Team Leader : Alexandre Djiane

Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5


Tél. : 33 (0)4 67 61 24 41
Fax : 33 (0)4 67 61 37 87

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© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés