Actualités
Séminaires

Jihane BASBOUS, PhD

Institut de Génétique Humaine (IGH), CNRS UMR 9002

Université de Montpellier, France

"Compartmentalization of the DNA damage response: Mechanisms and functions"

Our research investigates the molecular mechanisms and functions of protein compartmentalization in response to DNA damage and repair. Focusing on two critical scaffolding proteins, TopBP1 and SLX4, we have elucidated how their assembly into nanocondensate clusters following DNA damage activates specific signalling pathways. Our research aims to demonstrate how DNA repair foci, functioning as biomolecular condensates, link molecular mechanisms to cellular physiological functions. Our work offers valuable insights into the regulatory mechanisms of the DNA damage response compartmentalization and opens new avenues for developing innovative cancer management strategies.

Sébastien PAPOT

Institut de Chimie des Milieux  Matériaux de Poitiers (IC2MP)-ULR CNRS 7285

Professeur des Universités, Responsable de l'Equipe OrgaSynth

" Targeting the Tumor Microenvironment for Cancer Therapy and Diagnosis"

host : Eric Julien (IRCM)

Noboru MIZUSHIMA

Tokyo University (Japan)

"intracellular degradation and quality control by autophagy"

host: Sophie Pattingre (IRCM)

Autophagy is an intracellular degradation system conserved in many eukaryotes. In the process of autophagy, a portion of the cytoplasm is surrounded by autophagosomes and then delivered to lysosomes for degradation. Studies on the molecular mechanism and physiological function of autophagy have made remarkable progress over the past 20 years since the landmark genetic studies in yeast by Dr. Ohsumi and other groups. In this seminar, I will summarize the current status of autophagy research, including methodology, and discuss some recent topics on autophagosome-lysosome fusion, selective degradation of mitochondria by autophagy, and the reversibility of cellular dysfunction caused by autophagy defects.

Thomas DAUBON

Institut de Biochimie et Génétique Cellulaires, UMR 5095 CNRS Université de Bordeaux

"The PacMan effect : when glioblastoma cells eat myelin to invade the brain"

host : Julie Pannequin (IGF) / Laurent Le Cam (IRCM)

Arnaud BLOMME

Laboratory of Metabolic Regulation, GIGA-Research Institute, University of Liège, Belgique

"Targeting mTORC2-dependent metabolic vulnerabilities in lung cancer"

hôte: Andrei Turtoi (IRCM-Inserm)

Thierry DUBOIS

Institut Curie – Centre de Recherche, Département Recherche Translationnelle & CNRS UMR144  

Groupe « Biologie du Cancer du Sein »

“Protein arginine methyltransferases (PRMTs) in triple-negative breast cancer: potential targets and functional studies”

host : Eric JULIEN (IRCM)

Adélaïde RAGUIN

Institute For Computational Cell Biology

Heinrich-Heine University

Dusseldorf (Germany)

"Computational modeling of gene expression and its regulation : an approach based on stochastic simulations and bioinformatics"

host : Alexandre DAVID (IRCM-Inserm)

Nathalie LABARRIERE

INCIT, UMR1302 InsermHead of Team « anti-tumor immunosurveillance and Immunotherapy »IRS2, 22 boulevard Benoni Goullin44200 Nantes – France

"Optimizing T-cells for adoptive cell transfer approaches in melanoma"

host : Céline Gongora (IRCM-Inserm)