Institut de Génétique Humaine (IGH), CNRS UMR 9002
Université de Montpellier, France
Our research investigates the molecular mechanisms and functions of protein compartmentalization in response to DNA damage and repair. Focusing on two critical scaffolding proteins, TopBP1 and SLX4, we have elucidated how their assembly into nanocondensate clusters following DNA damage activates specific signalling pathways. Our research aims to demonstrate how DNA repair foci, functioning as biomolecular condensates, link molecular mechanisms to cellular physiological functions. Our work offers valuable insights into the regulatory mechanisms of the DNA damage response compartmentalization and opens new avenues for developing innovative cancer management strategies.
Institut de Chimie des Milieux Matériaux de Poitiers (IC2MP)-ULR CNRS 7285
Professeur des Universités, Responsable de l'Equipe OrgaSynth
host : Eric Julien (IRCM)
Tokyo University (Japan)
host: Sophie Pattingre (IRCM)
Autophagy is an intracellular degradation system conserved in many eukaryotes. In the process of autophagy, a portion of the cytoplasm is surrounded by autophagosomes and then delivered to lysosomes for degradation. Studies on the molecular mechanism and physiological function of autophagy have made remarkable progress over the past 20 years since the landmark genetic studies in yeast by Dr. Ohsumi and other groups. In this seminar, I will summarize the current status of autophagy research, including methodology, and discuss some recent topics on autophagosome-lysosome fusion, selective degradation of mitochondria by autophagy, and the reversibility of cellular dysfunction caused by autophagy defects.
Institut de Biochimie et Génétique Cellulaires, UMR 5095 CNRS Université de Bordeaux
host : Julie Pannequin (IGF) / Laurent Le Cam (IRCM)
Laboratory of Metabolic Regulation, GIGA-Research Institute, University of Liège, Belgique
hôte: Andrei Turtoi (IRCM-Inserm)
Institut Curie – Centre de Recherche, Département Recherche Translationnelle & CNRS UMR144
Groupe « Biologie du Cancer du Sein »
host : Eric JULIEN (IRCM)
Institute For Computational Cell Biology
Heinrich-Heine University
Dusseldorf (Germany)
host : Alexandre DAVID (IRCM-Inserm)
INCIT, UMR1302 InsermHead of Team « anti-tumor immunosurveillance and Immunotherapy »IRS2, 22 boulevard Benoni Goullin44200 Nantes – France
host : Céline Gongora (IRCM-Inserm)