Actualités
Séminaires

Isabelle ADER

CR Inserm,

Laboratoire Restore, Equipe Metabolink

UMR 1301 Inserm 5070, CNRS, Université Paul Sabatier (Toulouse)

"Multiscale approach to identify health markers related to aging"

Aging, is a physiological process often characterized by declining function over time and the primary risk factor for many age-related diseases, impacting health and survival. The World Health Organization (WHO) identifies five key domains to track health during aging, which can reveal frailty as a sign of unhealthy aging and precursor of dependency. Intrinsic capacity (IC) is a metric encompassing these five domains, reflecting the overall physical and mental abilities of an individual, and is now recognized as measurable and predictive of key attributes that support healthy aging. While certain blood biomarkers are linked to frailty syndrome in old individuals, there is a need for one or a set of biomarkers that can predict the risk of frailty in younger individuals. This would allow for the implementation of suitable preventive or intervention strategies to reduce the likelihood or severity of frailty. While IC is associated with comorbidities and frailty, no studies have been conducted to determine whether biomarkers of aging are associated with IC at all ages. The key challenge is to identify correlations between molecular markers and IC, which could improve our understanding of the mechanisms driving functional decline and provide valuable targets for early risk detection and intervention. Despite extensive research, a gap persists in linking systemic and cellular changes to broader aging phenotypes like IC and frailty. In our multiscale study, we aimed to identify functional health markers using samples from the INSPIRE human translational cohort (INSPIRE-T cohort). This cohort included 1000 participants for the plasma study and 133 for the skin fibroblast study, ranging in age from 20 to 96 years, and covering a spectrum of frailty levels (robust, pre-frail, frail) and IC scores. At the systemic scale, plasma samples allowed us to map energy metabolism associated with functional decline and IC, while at the cellular scale, dermal fibroblasts from skin biopsies helped identify health markers, molecular targets, and reveal mechanisms related to aging and IC.??

hôte : Pierre-François Roux (équipe Le Cam), IRCM

Olga  KATSARA

NYU Langone Medical Center, New York City (USA)

"DAP5 selective translation in triple negative breast Cancer"

hôte : Alexandre David (IRCM)

Ewan MacDonald

Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM)
Equipe "Dynamique du Cytosquelette et du Trafic Membranaire dans l'Adhérence"

CNRS UMR 5237

"Membrane trafficking controls invasive cell migration of triple negative breast cancer cells"

Hôte : Nathalie Bonnefoy (IRCM)

Mircea SOFONEA

Associate professor of epidemiology, University of Montpellier & CHU Nîmes

PCCEI (UM, Inserm, EFS) research unit

Research head of the ExposUM Institute

"On Airbone Transmission : history, biophysics, epidemiology & modeling"

Airborne transmission was an emblematic point of tension during the COVID pandemic. From its identification to its prevention, it represents both a scientific and a health issue. In this lecture, we will draw on recent reviews and key works in the literature, while situating older sources in the evolution of points of view on the subject, in an attempt to summarise the main historical, biophysical and epidemiological elements relating to airborne transmission, with an emphasis on the contributions of modelling to the study of this subject, now a public health priority.

Noted of, the scientific seminar will be followed by an institutional presentation of the ExposUM Institute.

host : Antonio MARAVER (IRCM)

Borhane GUEZGUEZ

Department Hematology and Medical Oncology, University Medical Center Mainz, Germany

"Advancing Cancer Therapy in Leukemia : The Intersection of Epigenetics, Inflammation and Tumor Microenvironment"

host : Alexandre Djiane (IRCM)

Eileen PARKES

Associate Professor,

Innate tumor Immunology laboratory

Oxford University, England

"Targeting immunosuppression in Chromosomally unstable cancers"

Dr Eileen Parkes is an early phase medical oncologist and associate professor at the University of Oxford. She completed her medical oncology training and PhD at Queens University Belfast before moving to Oxford in 2019. She leads early phase studies of novel IO, including STING agonsits, and is lead for Oxford Experimental Cancer Medicine Centre, focusing on translational research. Her lab team studies the tumour microenvironment of chromosomally unstable cancers, with a particular focus on cGAS-STING signalling, intending to identify novel therapeutic strategies for chromosomally unstable cancers including oesophageal adenocarcinomas.

host: Julien Faget (IRCM)

Mickaël Le Clech, PhD

Business Developer

ENSCM-USCBF-CN

"Discover your drug candidate with ChemBioFrance and the French National Chemical Library"

host : Eric JULIEN (IRCM)

Jihane BASBOUS, PhD

Institut de Génétique Humaine (IGH), CNRS UMR 9002

Université de Montpellier, France

"Compartmentalization of the DNA damage response: Mechanisms and functions"

Our research investigates the molecular mechanisms and functions of protein compartmentalization in response to DNA damage and repair. Focusing on two critical scaffolding proteins, TopBP1 and SLX4, we have elucidated how their assembly into nanocondensate clusters following DNA damage activates specific signalling pathways. Our research aims to demonstrate how DNA repair foci, functioning as biomolecular condensates, link molecular mechanisms to cellular physiological functions. Our work offers valuable insights into the regulatory mechanisms of the DNA damage response compartmentalization and opens new avenues for developing innovative cancer management strategies.