Purdue University Center for Cancer Research, West Lafayette, In. USA
Contact IRCM : Charles Theillet
Université de Zurich, Suisse
Contact IRCM : Nathalie Bonnefoy
Université de Zurich, Suisse
Contact IRCM : Nathalie Bonnefoy
Franck Vandemoere,
IGF, CNRS UMR5203, INSERM U1191, Montpellier
"Regulation by phosphorylation of two GPCRs targeted by antipsychotics"
Contact: pierre.martineau@inserm.fr
Giulio Preta
Life Science Center, Vilnius University, Lithuania
'Targeting lipid rafts as a strategy against infection and cancer"
Short summary of the work:
Lipid rafts are membrane micro-domains that are enriched in cholesterol, sphingomyelin, sphingolipids and phospholipids. Their importance for living cells is underlined by their involvement in many processes including bacterial and viral entry, cardiovascular and prion diseases as well as cancer. Targeting lipid rafts is emerging as an innovative strategy to limit bacterial or viral infection and to increase the sensitivity to apoptosis of different types of tumours. Behind well-known cholesterol depleting agents (cyclodextrin) new compounds involved in cholesterol homeostasis were recently discovered. These potential drug candidates are capable to modify the lipid rafts composition and to alter the signalling platform associated with them. Multiple technologies including confocal microscopy to visualize lipid rafts, viability assays to determine the toxic effect of compounds on the cells, offer the opportunity to study in details the changes induced by this new class of cholesterol-targeting agents.
Jérôme Déjardin
IGH, CNRS, Montpellier
"Atypical heterochromatin stimulates alternative lengthening of telomeres"
Contact: claude.sardet@inserm.fr
Julien Faget
ISREC/EPFL, Lausanne, Suisse
"Learning from models of immunotherapy resistant lung cancer"
Contact: nathalie.bonnefoy@inserm.fr
Julien Faget
ISREC/EPFL, Lausanne, Suisse
"Learning from models of immunotherapy resistant lung cancer"
Contact: nathalie.bonnefoy@inserm.fr
Situé dans le Parc Euromédecine, l'Institut de Recherche en Cancérologie de Montpellier (U1194) est localisé sur le Campus Val d'Aurelle (ICM, Institut régional du Cancer Montpellier / Val d'Aurelle).
Centre de Recherche U1194 soutenu par l'Inserm, l'Université de Montpellier et l'Institut du Cancer de Montpellier (ICM)
Institut de Recherche en Cancérologie de
