Recherche
Oncogénèse moléculaire : L. Le Cam

Liste des Publications

Batnini K, Kirsh O, Zaroual M, Delpech H, Fallet C, Lacroix M, Le Cam L, Theillet C, Sardet C, Rodier G Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer. Int J Mol Sci. 2022;23(16):9217. doi:10.3390/ijms23169217

Hodgkinson A, Trucu D, Lacroix M, Le Cam L, Radulescu O Computational Model of Heterogeneity in Melanoma: Designing Therapies and Predicting Outcomes. Front Oncol. 2022;12. doi:10.3389/fonc.2022.857572

Lahalle A, Lacroix M, De Blasio C, Cissé M, Linares L, Le Cam L The p53 Pathway and Metabolism: The Tree That Hides the Forest. Cancers. 2021;13(1):133. doi:10.3390/cancers13010133

Lacroix M, Linares L, Rueda-Rincon N, Bloch K, Di Michele M, De Blasio C, Fau C, Gayte L, Blanchet E, Mairal A, Derua R, Cardona F, Beuzelin D, Annicotte J-S, Pirot N, Torro A, Tinahones F, Bernex F, Bertrand-Michel J, Langin D, Fajas L, Swinnen J, Le Cam L The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes. Nat Commun. 2021;12(1):7037. doi:10.1038/s41467-021-27307-3

Wendling O, Hentsch D, Jacobs H, Lemercier N, Taubert S, Pertuy F, Vonesch J-L, Sorg T, Di Michele M, Le Cam L, Rosahl T, Carballo-Jane E, Liu M, Mu J, Mark M, Herault Y High Resolution Episcopic Microscopy for Qualitative and Quantitative Data in Phenotyping Altered Embryos and Adult Mice Using the New "Histo3D" System. Biomedicines. 2021;9(7):767. doi:10.3390/biomedicines9070767

Rodríguez-Mier P, Poupin N, Le Cam L, Jourdan F, Kaleta C DEXOM: Diversity-based enumeration of optimal context-specific metabolic networks. PLoS Comput Biol. 2021;17(2):e1008730. doi:10.1371/journal.pcbi.1008730

Cristea S, Coles G, Hornburg D, Gershkovitz M, Arand J, Cao S, Sen T, Williamson S, Kim J, Drainas A, He A, Cam L, Byers L, Snyder M, Contrepois K, Sage J The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer. Cancer Res. 2020;80(6):1293-1303. doi:10.1158/0008-5472.CAN-19-1027

Cissé M, Pyrdziak S, Firmin N, Gayte L, Heuillet M, Bellvert F, Fuentes M, Delpech H, Riscal R, Arena G, Chibon F, Le Gellec S, Maran-Gonzalez A, Chateau M-C, Theillet C, Portais J-C, Le Cam L, Linares L Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma. Sci. Transl. Med.. 2020;12(547):eaay2163. doi:10.1126/scitranslmed.aay2163

Lacroix M, Riscal R, Arena G, Linares L, Le Cam L Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer. Mol Metab. 2020;33. doi:10.1016/j.molmet.2019.10.002

Quénet F, Pissas M-H, Gil H, Roca L, Carrère S, Sgarbura O, Rouanet P, de Forges H, Khellaf L, Deshayes E, Ychou M, Bibeau F Two-stage hepatectomy for colorectal liver metastases: Pathologic response to preoperative chemotherapy is associated with second-stage completion and longer survival. 2019;165(4):703-711. doi:10.1016/j.surg.2018.10.006

Darlix A, Hirtz C, Thezenas S, Maceski A, Gabelle A, Lopez-Crapez E, Firmin N, Guiu S, Jacot W, Lehmann S The prognostic value of the Tau protein serum level in metastatic breast cancer patients and its correlation with brain metastases. 2019;19(1). doi:10.1186/s12885-019-5287-z

Champagne J, Linares L, Maurel B, Zampieri A, Moreno M, Fuentes I, Dubois E, Severac D, Decorsière A, Bienvenu F TAG-RNAi overcomes off-target effects in cancer models. Oncogene. Sep 26, 2019. doi:10.1038/s41388-019-1020-2

Pons-Tostivint E, Kirova Y, Campone M, Geffrelot J, Mazouni C, Mailliez A, Pasquier D, Madranges N, Firmin N, Crouzet A, Jankowski C, De La Motte Rouge T, Pouget N, de La Lande B, Mouttet-Boizat D, Ferrero J-M, Uwer L, Eymard J-C, Mouret-Reynier M-A, Petit T, Robain M, Filleron T, Cailliot C, Dalenc F Survival Impact of Locoregional Treatment of the Primary Tumor in De Novo Metastatic Breast Cancers in a Large Multicentric Cohort Study: A Propensity Score-Matched Analysis. 2019;26(2):356-365. doi:10.1245/s10434-018-6831-9

Blay J-Y, Honoré C, Stoeckle E, Jafari M, Gouin F, Anract P, Ferron G, Rochwerger A, Ropars M, Carrere S, Marchal F, Sirveaux F, Di Marco A, Le Nail L, Guiramand J, Vaz G, Machiavello J-C, Marco O, Causeret S, Gimbergues P, Fiorenza F, Chaigneau L, Guillemin F, Guilloit J-M, Dujardin F, Spano J-P, Ruzic J-C, Michot A, Soibinet P, Bompas E, Chevreau C, Duffaud F, Rios M, Perrin C, Firmin N, Bertucci F, Le Loarer F, Collard O, Karanian-Philippe M, Brahmi M, Dufresne A, Dupré A, Ducimetière F, Giraud A, Pérol D, Toulmonde M, Ray-Coquard I, Italiano A, Le Cesne A, Penel N, Bonvalot S Surgery in reference centers improves survival of sarcoma patients: a nationwide study. Ann. Oncol.. 06 05, 2019. doi:10.1093/annonc/mdz170

Hodgkinson A, Le Cam L, Trucu D, Radulescu O Spatio-Genetic and phenotypic modelling elucidates resistance and re-sensitisation to treatment in heterogeneous melanoma. Journal of Theoretical Biology. 2019;466. doi:10.1016/j.jtbi.2018.11.037

Tetreau R, Honoré C, Tzanis D, Delhorme J-B, Fau M, Decanter G, Llacer C, Firmin N, Stoeckle E, Ferron G, Cupissol D, Meunier B, Bonvalot S Quelle prise en charge optimale pour un sarcome du cordon spermatique en 2018 ?. 2019;29(1):12-17. doi:10.1016/j.purol.2018.09.010

Arena G, Cissé M, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold J, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Marine J-C, Etienne-Manneville S, Bernex F, Lombès A, Cameron C, Dubouchaud H, Ricchetti M, Linares L, Le Cam L Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53. Mol. Cell. 2018;69(4):594-609.e8. doi:10.1016/j.molcel.2018.01.023

Arena G, Riscal R, Linares L, Le Cam L MDM2 controls gene expression independently of p53 in both normal and cancer cells. Cell Death Differ.. 2018;25(9):1533-1535. doi:10.1038/s41418-018-0156-x

Bertoli S, Picard M, Bérard E, Griessinger E, Larrue C, Mouchel P, Vergez F, Tavitian S, Yon E, Ruiz J, Delabesse E, Luquet I, Linares L, Saland E, Carroll M, Danet-Desnoyers G, Sarry A, Huguet F, Sarry J, Récher C Dexamethasone in hyperleukocytic acute myeloid leukemia. Haematologica. 2018;103(6):988-998. doi:10.3324/haematol.2017.184267

Delhorme J-B, Severac F, Averous G, Glehen O, Passot G, Bakrin N, Marchal F, Pocard M, Lo Dico R, Eveno C, Carrere S, Sgarbura O, Quenet F, Ferron G, Goéré D, Brigand C Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei of appendicular and extra-appendicular origin: Treatment of appendicular and extra-appendicular pseudomyxoma peritonei. 2018;105(6):668-676. doi:10.1002/bjs.10716

Griguolo G, Pouderoux S, Dieci M, Jacot W, Bourgier C, Miglietta F, Firmin N, Viala M, Guarneri V, Darlix A Clinicopathological and Treatment?Associated Prognostic Factors in Patients with Breast Cancer Leptomeningeal Metastases in Relation to Tumor Biology. 2018;23(11):1289-1299. doi:10.1634/theoncologist.2018-0200

Montagner A, Le Cam L, Guillou H ?-catenin oncogenic activation rewires fatty acid catabolism to fuel hepatocellular carcinoma. Gut. Aug 04, 2018. doi:10.1136/gutjnl-2018-316557

Gelmetti V, De Rosa P, Torosantucci L, Marini E, Romagnoli A, Di Rienzo M, Arena G, Vignone D, Fimia G, Valente E PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation. Autophagy. 2017;13. doi:10.1080/15548627.2016.1277309

Farge T, Saland E, de Toni F, Aroua N, Hosseini M, Perry R, Bosc C, Sugita M, Stuani L, Fraisse M, Scotland S, Larrue C, Boutzen H, Feliu V, Nicolau-Travers M, Cassant-Sourdy S, Broin N, David M, Serhan N, Sarry A, Tavitian S, Kaoma T, Vallar L, Iacovoni J, Linares L, Montersino C, Castellano R, Griessinger E, Collette Y, Duchamp O, Barreira Y, Hirsch P, Palama T, Gales L, Delhommeau F, Garmy-Susini B, Portais J, Vergez F, Selak M, Danet-Desnoyers G, Carroll M, Recher C, Sarry J Chemotherapy Resistant Human Acute Myeloid Leukemia Cells are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism. Cancer discovery. Apr 17 2017. doi:10.1158/2159-8290.CD-16-0441

Bertrand M, Colombo P-E, Mourregot A, Traore D, Carrère S, Quénet F, Rouanet P Standardized single docking, four arms and fully robotic proctectomy for rectal cancer: the key points are the ports and arms placement. 2016;10(2):171-174. doi:10.1007/s11701-015-0551-y



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