
Institut de Génétique Moléculaire de Montpellier (IGMM) CNRS-UMR 5535
Route de Mende, Montpellier
Dr. Gregoire and his collaborators develop innovative murine models to study liver cancer heterogenity. They explore how the genetic composition of hepatocarcinoma influences their development, their interaction with the microenvironment, and their response to therapies.
Université Cote d'Azur,
Institut de Recherche Cancer et Vieillissement de Nice (IRCAN)
UMR CNRS 7284/U Inserm 1081
hôte : Alexandre DAVID (IRCM)
Group Leader, Tumor Immunotherapy and Microenvironment
Luxembourg Institute of Health, Department of Cancer Research
contact : Andrei Turtoi (IRCM)
Equipe "Génétique et développement des tumeurs cérébrales"
Institut du Cerveau / ICM
Hôpital de la Pitié-Salpêtrière
CNRS UMR7225-Inserm U1127-Sorbonne Université
contact : Lucille STUANI (IRCM)
Institut de Chimie des Milieux Matériaux de Poitiers (IC2MP)-ULR CNRS 7285
Professeur des Universités, Responsable de l'Equipe OrgaSynth
host : Eric Julien (IRCM)
Tokyo University (Japan)
host: Sophie Pattingre (IRCM)
Autophagy is an intracellular degradation system conserved in many eukaryotes. In the process of autophagy, a portion of the cytoplasm is surrounded by autophagosomes and then delivered to lysosomes for degradation. Studies on the molecular mechanism and physiological function of autophagy have made remarkable progress over the past 20 years since the landmark genetic studies in yeast by Dr. Ohsumi and other groups. In this seminar, I will summarize the current status of autophagy research, including methodology, and discuss some recent topics on autophagosome-lysosome fusion, selective degradation of mitochondria by autophagy, and the reversibility of cellular dysfunction caused by autophagy defects.
Institut de Biochimie et Génétique Cellulaires, UMR 5095 CNRS Université de Bordeaux
host : Julie Pannequin (IGF) / Laurent Le Cam (IRCM)
Laboratory of Metabolic Regulation, GIGA-Research Institute, University of Liège, Belgique
hôte: Andrei Turtoi (IRCM-Inserm)